![]() ![]() ![]() We show that DENV infection increases thermal sensitivity, an effect that may ultimately limit the geographic range of the virus. Such laboratory measures of thermal tolerance have previously been shown to accurately predict an insect’s distribution in the field. aegypti thermotolerance by using a high-throughput physiological ‘knockdown’ assay modeled on studies in Drosophila. ![]() Here, we examine how DENV infection alters Ae. When temperatures fluctuate, mosquito vectors will be increasingly exposed to temperatures beyond their upper thermal limits. As consequences of climate change, we expect an increase in both global mean temperatures and extreme climatic events. The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever.
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